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Passive immunization experiments using intra-peritoneal injections …Five melanocortin receptors have been identified: Melanocyte-stimulating hormone receptor (MSH-R), now termed MC1-R: Expressed on melanocytes and responsible for different pigmentations.
MC1/Alz50 are currently the only antibodies targeting a disease-specific conformational modification of tau. Mc1 Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for immunotherapy in Alzheimer’s disease (AD) and other tauopathies.
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